posted on 2021-04-13, 18:40authored byLu Liu, Juanyan Wu, Shuanghu Wang, Liu Kun, Junbin Gao, Bin Chen, Yicheng Ye, Fei Wang, Fei Tong, Jiamiao Jiang, Juanfeng Ou, Daniela A. Wilson, Yingfeng Tu, Fei Peng
Inducing
neural stem cells to differentiate and replace degenerated
functional neurons represents the most promising approach for neural
degenerative diseases including Parkinson’s disease, Alzheimer’s
disease, etc. While diverse strategies have been proposed in recent
years, most of these are hindered due to uncontrollable cell fate
and device invasiveness. Here, we report a minimally invasive micromotor
platform with biodegradable helical Spirulina plantensis (S. platensis) as the framework and superparamagnetic
Fe3O4 nanoparticles/piezoelectric BaTiO3 nanoparticles as the built-in function units. With a low-strength
rotational magnetic field, this integrated micromotor system can perform
precise navigation in biofluid and achieve single-neural stem cell
targeting. Remarkably, by tuning ultrasound intensity, thus the local
electrical output by the motor, directed differentiation of the neural
stem cell into astrocytes, functional neurons (dopamine neurons, cholinergic
neurons), and oligodendrocytes, can be achieved. This micromotor platform
can serve as a highly controllable wireless tool for bioelectronics
and neuronal regenerative therapy.