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Continuous Synthesis and Use of N‑Heterocyclic Carbene Copper(I) Complexes from Insoluble Cu2O

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journal contribution
posted on 01.03.2013, 00:00 by Suzanne M. Opalka, Jin Kyoon Park, Ashley R. Longstreet, D. Tyler McQuade
It is demonstrated that homogeneous N-heterocyclic carbene–copper(I)-chloride complexes can be prepared continuously by flowing NHC precursors through a packed bed of solid Cu2O suspended in molecular sieves. The method enables the synthesis of a wide range of complexes including those that are challenging to prepare using standard approaches. Our strategy enables both sustained output of complex production for long-term catalytic reactions (greater than 5 h) and for generation of gram quantities for storage (greater than 1 g of complex in ∼16 min).