Continuous Photochemical Cleavage of Linkers for Solid-Phase Synthesis
journal contributionposted on 2014-03-21, 00:00 authored by Mattan Hurevich, Jeyakumar Kandasamy, Bopanna M. Ponnappa, Mayeul Collot, Daniel Kopetzki, D. Tyler McQuade, Peter H. Seeberger
Photolabile linkers are an attractive alternative for solid-phase synthesis because they can be cleaved using light. However, irradiation in a classical batch photoreactor results in incomplete cleavage of the photolabile linkers. It is demonstrated that a continuous flow photoreactor is superior to a batch photoreactor for the cleavage of a linker from polystyrene resin.