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Continuous Photochemical Cleavage of Linkers for Solid-Phase Synthesis

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journal contribution
posted on 21.03.2014, 00:00 by Mattan Hurevich, Jeyakumar Kandasamy, Bopanna M. Ponnappa, Mayeul Collot, Daniel Kopetzki, D. Tyler McQuade, Peter H. Seeberger
Photolabile linkers are an attractive alternative for solid-phase synthesis because they can be cleaved using light. However, irradiation in a classical batch photoreactor results in incomplete cleavage of the photolabile linkers. It is demonstrated that a continuous flow photoreactor is superior to a batch photoreactor for the cleavage of a linker from polystyrene resin.

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