ol500530q_si_003.pdf (392.18 kB)
Continuous Photochemical Cleavage of Linkers for Solid-Phase Synthesis
journal contribution
posted on 2014-03-21, 00:00 authored by Mattan Hurevich, Jeyakumar Kandasamy, Bopanna
M. Ponnappa, Mayeul Collot, Daniel Kopetzki, D. Tyler McQuade, Peter H. SeebergerPhotolabile linkers are an attractive
alternative for solid-phase
synthesis because they can be cleaved using light. However, irradiation
in a classical batch photoreactor results in incomplete cleavage of
the photolabile linkers. It is demonstrated that a continuous flow
photoreactor is superior to a batch photoreactor for the cleavage
of a linker from polystyrene resin.
