posted on 2020-03-24, 11:06authored byRupesh
K. Mishra, K. Yugender Goud, Zhanhong Li, Chochanon Moonla, Mona A. Mohamed, Farshad Tehrani, Hazhir Teymourian, Joseph Wang
There are urgent needs for sensing
devices capable of distinguishing
between episodes of opioid overdose and nerve agent poisoning. This
work presents a wearable microneedle sensor array for minimally invasive
continuous electrochemical detection of opioid (OPi) and organophosphate
(OP) nerve agents on a single patch platform. The new multimodal microneedle
sensor array relies on unmodified and organophosphorus hydrolase (OPH)
enzyme-modified carbon paste (CP) microneedle electrodes for square
wave voltammetric (SWV) detection of the fentanyl and nerve agent
targets, respectively. Such real-time simultaneous sensing provides
distinct unique information, along with attractive analytical performance,
including high sensitivity, selectivity, and stability, for real-time
on-body OPi–OP analysis. The patch represents the first sensing
device capable of continuously monitoring fentanyl down to the nanomolar
level through a nanomaterial-based multilayered surface architecture.
Applicability of the sensor array toward opioids screening is demonstrated
for morphine and norfentanyl. Successful OPi–OP detection conducted
in a skin-mimicking phantom gel demonstrates the suitability of the
device for rapid on-body sensing. Such progress toward continuous
minimally invasive transdermal analysis of drugs of abuse and nerve
agents holds promise for rapid countermeasures for protecting soldiers,
civilians, and healthcare personnel.