Construction of a Spirooxindole Amide Library through
Nitrile Hydrozirconation-Acylation-Cyclization Cascade

LaPorte, Matthew G.; Tsegay, Sammi; Hong, Ki Bum; Lu, Chunliang; Fang, Cheng; Wang, Lirong; Xie, Xiang-Qun; Floreancig, Paul E.

doi:10.1021/co4000387.s002

Construction of a Spirooxindole Amide Library through Nitrile Hydrozirconation-Acylation-Cyclization Cascade

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posted on 2016-02-19, 04:08 authored by Matthew G. LaPorte, Sammi Tsegay, Ki Bum Hong, Chunliang Lu, Cheng Fang, Lirong Wang, Xiang-Qun Xie, Paul E. Floreancig

A library of spirooxindoles containing varied elements of structural and stereochemical diversity has been constructed via a three step, one pot nitrile hydrozirconation-acylation-cyclization reaction sequence from common acyclic indole intermediates. The resulting library was evaluated for novelty through comparison with MLSMR and Maybridge compound collections.

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sequence novelty Spirooxindole Amide Library MLSMR stereochemical diversity spirooxindole Maybridge compound collections Construction Nitrile acyclic indole intermediates CascadeA nitrile

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Construction of a Spirooxindole Amide Library through Nitrile Hydrozirconation-Acylation-Cyclization Cascade

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