Construction of Methylenecycloheptane Frameworks through 7-Exo-Dig Cyclization of Acetylenic Silyl Enol Ethers Catalyzed by Triethynylphosphine−Gold Complex
journal contributionposted on 01.10.2010, 00:00 authored by Hideto Ito, Hirohisa Ohmiya, Masaya Sawamura
A cationic gold(I) complex bearing a semihollow-shaped triethynylphosphine ligand efficiently catalyzed the 7-exo-dig cyclization of silyl enol ethers with an ω-alkynic substituent. The reaction gave various methylenecycloheptane derivatives with an exo- or endocyclic carbonyl group. The protocol was applicable not only to cyclic substrates that form bicyclic frameworks but also to acyclic ones with or without substituents in a carbon chain tether.
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carbon chain tetherCyclizationComplexConstructionmethylenecycloheptane derivativesligandcationiccyclizationMethylenecycloheptane Frameworkscyclic substratesendocyclic carbonyl groupalkynicform bicyclic frameworkssubstituentAcetylenic Silyl Enol Ethers Catalyzedacyclic onesexoTriethynylphosphinesilyl enol etherstriethynylphosphine