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Construction of Hydrodibenzo[b,d]furan Frameworks from Morita–Baylis–Hillman Carbonates of Isatins and o‑Hydroxy Enones via Palladium and Brønsted Base Relay Catalysis
journal contribution
posted on 2021-12-10, 13:36 authored by Ze-Liang He, Peng Chen, Zhi-Chao Chen, Wei Du, Ying-Chun ChenA cascade assembly between isatin-derived
Morita–Baylis–Hillman
carbonates and o-hydroxybenzylideneacetones has been
developed under the relay catalysis of Pd(PPh3)4 and DBU, affording a spectrum of 1,2,3,4-tetrahydrodibenzo[b,d]furan architectures incorporating a
spirooxindole motif in moderate to good yields with excellent diastereoselectivity.
The fused indole analogues were similarly furnished by employing the
benzylideneacetones having an o-TsNH group.