ol8b03363_si_001.pdf (6.8 MB)
Construction of Azepino[2,3‑b]indole Core via Sulfur Ylide Mediated Annulations
journal contribution
posted on 2018-11-16, 19:39 authored by Jun-Long Li, Qing-Song Dai, Kai-Chuan Yang, Yue Liu, Xiang Zhang, Hai-Jun Leng, Cheng Peng, Wei Huang, Qing-Zhu LiA novel
[4 + 3] annulation of indoline-based aza-dienes and crotonate-derived
sulfur ylides is described. This method could be further expanded
by using more efficient synthetic strategies, including three-component
[3 + 1 + 3] cascade and the direct sulfide-catalyzed [4 + 3] cyclization.
These protocols enable the rapid construction of azepino[2,3-b]indole cores, and a broad spectrum of the desired products
with diverse substituents was facilely accessed in generally high
yield.