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Concise Total Synthesis of (±)-Aloperine and 6-epi-Aloperine

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journal contribution
posted on 27.07.2002, 00:00 by Daniele Passarella, Marco Angoli, Alessandra Giardini, Giordano Lesma, Alessandra Silvani, Bruno Danieli
Total synthesis of aloperine and 6-epi-aloperine is reported. The crucial steps of the synthetic strategy are an aza-annulation reaction and an intermolecular Diels−Alder reaction. The synthetic plan proceeds from commercially available piperidine-2-ethanol.