American Chemical Society
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Concise Synthesis of the Oxapentacyclic Core of Cortistatin A

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journal contribution
posted on 2010-11-19, 00:00 authored by Fangmiao Yu, Guozhi Li, Peng Gao, Hongju Gong, Yinghua Liu, Yongming Wu, Bin Cheng, Hongbin Zhai
A concise synthetic approach for constructing the oxapentacyclic framework of cortistatin A is described. The synthesis features a furan−oxyallyl [4 + 3] cycloaddition and double-intramolecular aldol reactions. In addition, an interesting core structure was obtained in 11 steps from furan by using our method.