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Concise Synthesis of the Bacterial DNA Primase Inhibitor (+)-Sch 642305

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journal contribution
posted on 29.03.2007, 00:00 by Erica M. Wilson, Dirk Trauner
A highly convergent, enantioselective synthesis of (+)-Sch 642305 is presented, which features a Mukaiyama−Michael addition followed by allylation to establish the syn−anti relationship of the three contiguous stereocenters. The 10-membered macrolactone was formed through ring-closing metathesis.