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Complementary Effects of Porosigen and Stabilizer on the Structure of Hollow Porous Poly(lactic-co-glycolic acid) Microparticles
journal contribution
posted on 2020-08-03, 11:35 authored by Xiaoqian Su, Ipshita Gupta, Umesh Sai Jonnalagadda, James J. KwanPoly(lactic-co-glycolic acid) (PLGA) plays a pivotal
role in both conventional and emerging drug delivery applications.
In this paper, we utilize a facile synthesis strategy to fabricate
PLGA microparticles with shapes including the conventional hollow
sphere and exotic shapes such as multicavity particles and cage-like
particles. These shapes are obtainable at sizes between 0.6 and 6
μm in diameter. Electron microscopy images indicated the presence
of water droplets in the oil phase of the emulsion, suggesting that
excess salinity in the aqueous core facilitated water permeation from
the bulk aqueous solution through the organic layer. These aqueous
droplets in the oil phase later become the pores and surface cavities
on the particles. Using Rhodamine B as a model drug, we measured both
loading efficiencies and payload release profiles for all PLGA formulations
and indicated a correlation between particle shape and drug release
mechanism. Our report elucidates the roles of stabilizers and porosigens
on the control of both size and shape of PLGA microparticles, providing
a simple framework to produce a wide range of loadable PLGA microparticles
with exotic shapes.