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Comparison of the Cardiac MicroPET Images Obtained Using [18F]FPTP and [13N]NH3 in Rat Myocardial Infarction Models

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journal contribution
posted on 09.10.2014, 00:00 by Dong-Yeon Kim, Hyeon Sik Kim, Hwa Youn Jang, Ju Han Kim, Hee-Seung Bom, Jung-Joon Min
The short half-life of current positron emission tomography (PET) cardiac tracers limits their widespread clinical use. We previously developed a 18F-labeled phosphonium cation, [18F]­FPTP, that demonstrated sharply defined myocardial defects in a corresponding infarcted myocardium. The aim of this study was to compare the image properties of PET scans obtained using [18F]­FPTP with those obtained using [13N]­NH3 in rat myocardial infarction models. Perfusion abnormality was analyzed in 17 segments of polar map images. The myocardium-to-liver and myocardium-to-lung ratios of [18F]­FPTP were 10.48 and 2.65 times higher, respectively, than those of [13N]­NH3 in images acquired 30 min after tracer injection. The myocardial defect size measured by [18F]­FPTP correlated more closely with the hypoperfused area measured by quantitative 2,3,5-triphenyltetrazolium chloride staining (r = 0.89, P < 0.01) than did [13N]­NH3 (r = 0.84, P < 0.01). [18F]­FPTP might be useful as a replacement for the myocardial agent [13N]­NH3 in cardiac PET/CT applications.