posted on 2018-07-05, 00:00authored byMengyang Xu, Fanyi Zhong, Richard S. Bruno, Kevin D. Ballard, Jing Zhang, Jiangjiang Zhu
Although
higher intakes of dairy milk are associated with a lower
risk of metabolic syndrome (MetS), the underlying protective mechanism
remains unclear. This study investigated the dynamic metabolic profile
shift following the ingestion of low-fat milk or an isocaloric volume
of rice milk in obese individuals with metabolic syndrome (MetS).
In a randomized, double-blind, crossover study, postprandial plasma
samples (n = 266) were collected from 19 MetS participants.
Plasma samples were analyzed by a targeted metabolomics platform which
specifically detects 117 metabolites from 25 metabolic pathways. The
comprehensive time-course metabolic profiling in MetS participants
indicated that the postprandial metabolic profiles distinguish low-fat
milk and rice milk consumption in a time-dependent manner. Metabolic
biomarkers, such as orotate, leucine/isoleucine and adenine, showed
significantly different trends in the two test beverages. Bayesian
statistics identified 12 metabolites associated with clinical characteristics
of postprandial vascular endothelial function, such as flow-mediated
dilation (FMD), postprandial plasma markers of oxidative stress and
NO status. Furthermore, metabolic pathway analysis based on these
metabolite data indicated the potential utility of metabolomics to
provide mechanistic insights of dietary interventions to regulate
postprandial metabolic excursions.