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Commercial Manufacturing of Propofol: Simplifying the Isolation Process and Control on Related Substances

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journal contribution
posted on 17.01.2014, 00:00 by Chinmoy Pramanik, Sandeep Kotharkar, Pradip Patil, Dinkar Gotrane, Yogesh More, Ajit Borhade, Balaji Chaugule, Tushar Khaladkar, K. Neelakandan, Ashok Chaudhari, Mukund G. Kulkarni, Narendra K. Tripathy, Mukund K. Gurjar
A commercially viable manufacturing process for propofol (1) is described. The process avoids acid–base neutralization events during isolation of intermediate, 2,6-di-isopropylbenzoic acid (3) and crude propofol, and thus simplifies the synthesis on industrial scale to a considerable extent. Syntheses of five impurities/related substances (USP and EP) are also described.