Commercial
Manufacturing of Propofol: Simplifying
the Isolation Process and Control on Related Substances

Pramanik, Chinmoy; Kotharkar, Sandeep; Patil, Pradip; Gotrane, Dinkar; More, Yogesh; Borhade, Ajit; Chaugule, Balaji; Khaladkar, Tushar; Neelakandan, K.; Chaudhari, Ashok; Kulkarni, Mukund
G.; Tripathy, Narendra K.; Gurjar, Mukund K.

doi:10.1021/op400300t.s001

Commercial Manufacturing of Propofol: Simplifying the Isolation Process and Control on Related Substances

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posted on 2014-01-17, 00:00 authored by Chinmoy Pramanik, Sandeep Kotharkar, Pradip Patil, Dinkar Gotrane, Yogesh More, Ajit Borhade, Balaji Chaugule, Tushar Khaladkar, K. Neelakandan, Ashok Chaudhari, Mukund G. Kulkarni, Narendra K. Tripathy, Mukund K. Gurjar

A commercially viable manufacturing process for propofol (1) is described. The process avoids acid–base neutralization events during isolation of intermediate, 2,6-di-isopropylbenzoic acid (3) and crude propofol, and thus simplifies the synthesis on industrial scale to a considerable extent. Syntheses of five impurities/related substances (USP and EP) are also described.

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Propofol manufacturing process acid Isolation Process neutralization Synthese USP synthesis crude propofol Simplifying extent Related SubstancesA EP impurity isolation Commercial Manufacturing

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Commercial Manufacturing of Propofol: Simplifying the Isolation Process and Control on Related Substances

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