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Combinatorial Photothermal and Immuno Cancer Therapy Using Chitosan-Coated Hollow Copper Sulfide Nanoparticles

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journal contribution
posted on 17.12.2015, 02:52 by Liangran Guo, Daisy D. Yan, Dongfang Yang, Yajuan Li, Xiaodong Wang, Olivia Zalewski, Bingfang Yan, Wei Lu
Near-infrared light-responsive inorganic nanoparticles have been shown to enhance the efficacy of cancer photothermal ablation therapy. However, current nanoparticle-mediated photothermal ablation is more effective in treating local cancer at the primary site than metastatic cancer. Here, we report the design of a near-infrared light-induced transformative nanoparticle platform that combines photothermal ablation with immuno­therapy. The design is based on chitosan-coated hollow CuS nanoparticles that assemble the immuno­adjuvants oligo­deoxy­nucleo­tides containing the cytosine-guanine (CpG) motifs. Interestingly, these structures break down after laser excitation, reassemble, and transform into polymer complexes that improve tumor retention of the immuno­therapy. In this “photothermal immuno­therapy” approach, photothermal ablation-induced tumor cell death reduces tumor growth and releases tumor antigens into the surrounding milieu, while the immuno­adjuvants potentiate host anti­tumor immunity. Our results indicated that combined photothermal immuno­therapy is more effective than either immuno­therapy or photothermal therapy alone against primary treated and distant untreated tumors in a mouse breast cancer model. These hollow CuS nanoparticles are biodegradable and can be eliminated from the body after laser excitation.