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Colorimetric Sensing of α-Amino Acids and Its Application for the “Label-Free” Detection of Protease

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journal contribution
posted on 02.02.2010, 00:00 by Xiaoding Lou, Liyao Zhang, Jingui Qin, Zhen Li
A new indirect approach to explore sensitive colorimetric sensors toward α-amino acids is proposed: the pink solution of 1 and copper ions changed to colorless immediately upon the addition of α-amino acids. As the hydrolysis of bovine serum albumin (BSA) with the aid of trypsin produces α-amino acids, the complex of 1/Cu2+/BSA could act as a label-free, sensitive, selective sensor toward trypsin. The detection process could be visually observed by naked eyes.