ao8b01813_si_001.pdf (3.02 MB)
Colorimetric Calcium Probe with Comparison to an Ion-Selective Optode
journal contribution
posted on 2018-10-03, 08:13 authored by Changyou Zhu, Manling Huang, Jialing Lan, Lung Wa Chung, Xin Li, Xiaojiang XieDesign strategies for small molecular
probes lay the foundation
of numerous synthetic chemosensors. A water-soluble colorimetric calcium
molecular probe inspired by the ionophore-based ion-selective optode
is presented here with a tunable detection range (around micromolar
at pH 7). The binding of Ca2+ resulted in the deprotonation
of the probe and thus a significant spectral change, mimicking the
ion-exchange process in ion-selective optodes. The 1:1 exchange between
Ca2+ and H+ was confirmed with Job’s
plot. Computational studies revealed possible monomer and dimer forms
of the probe–Ca2+ complexes.