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Color Test for Selective Detection of Secondary Amines on Resin and in Solution

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journal contribution
posted on 21.11.2014, 00:00 by Ulrik Boas, Sahar Mirsharghi
Resins for solid-phase synthesis give orange to red-brown resin beads selectively when secondary amines are present on the resin when treated with a solution of acetaldehyde and an Fmoc-amino acid in NMP. The method shows good specificity and gives colorless beads when exposed to a variety of other functional groups. Furthermore, the acetaldehyde/Fmoc amino acid method can be used as a selective colorimetric test for secondary amines in solution.