American Chemical Society
op8b00259_si_001.pdf (2.95 MB)

Collaborative Evaluation of Commercially Available Automated Powder Dispensing Platforms for High-Throughput Experimentation in Pharmaceutical Applications

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journal contribution
posted on 2018-10-09, 00:00 authored by Matthew N. Bahr, David B. Damon, Simon D. Yates, Alexander S. Chin, J. David Christopher, Samuel Cromer, Nicholas Perrotto, Jorge Quiroz, Victor Rosso
Many workflows in Pharmaceutical R&D involve the manipulation of defined amounts of powders. Automated powder dispensing platforms are currently available; however, these existing technologies do not meet the requirements for every high-throughput experimentation powder dispensing application. A Working Group (WG) composed of pharmaceutical researchers within the Enabling Technologies Consortium (ETC) evaluated automated platforms commercially available from three manufacturers using an objective, systematic testing protocol. This paper describes the selection of powders and testing conditions used in this evaluation, and it assesses the impact that the powders, testing conditions, equipment environment, and other factors had on the performance of the selected platforms.