posted on 2024-02-26, 07:03authored byYan Fang, Yukai Lin, Linyu Wang, Qinhui Chen, Yunxiang Weng, Caixia Sun, Haiqing Liu
Hemostatic powder is commonly used in emergency bleeding
control
due to its suitability for irregularly shaped wounds, ease of use,
and stable storage. However, traditional powder often has limited
tissue adhesion and weak thrombus support, which makes it vulnerable
to displacement by blood flow. Herein, we have developed a tricomponent
hemostatic powder (MQS) composed of mesoporous bioactive glass nanoparticle
(MBG), positively charged quaternized chitosan (QCS), and negatively
charged catechol-modified alginate (SADA). Upon application to the
wound, MBG with its high specific surface area quickly absorbs plasma,
concentrating the blood coagulation factor. Simultaneously, the water-soluble
QCS and SADA interact with each other and form a net, which can be
further cross-linked by MBG. This network efficiently binds and entraps
clustered blood coagulation factors, ultimately resulting in the formation
of a durable and robust thrombus. Furthermore, the formed net adheres
to the injury site, offering protection against thrombus disruption
caused by the bloodstream. Benefiting from the synergistic effect
of these three components, MQS demonstrates superior hemostatic performance
compared to commercial hemostatic powders like Celox in both arterial
injuries and noncompressible liver puncture wounds. Furthermore, MQS
can effectively accelerate wound healing. In addition, MQS exhibits
excellent antibacterial activity, cytocompatibility, and hemocompatibility.
These advantages of MQS, including strong blood clotting, wet tissue
adherence, antibacterial activity, wound healing ability, biosafety,
ease of use, and stable storage, make it a promising hemostatic agent
for emergency situations.