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Cognitive Enhancement by SGS742 in OF1 Mice Is Linked to Specific Hippocampal Protein Expression

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journal contribution
posted on 2008-12-05, 00:00 authored by Berta Sunyer, Wei-Fei Diao, Sung Ung Kang, Gunyong An, Sanjay Boddul, Gert Lubec
Cognitive enhancement by the GABA (B) antagonist SGS742 has been reported and we decided to search for proteins involved. Hippocampi from OF1 mice were from SGS742- treated animals and three control groups. Proteins were extracted and run on 2DE, and spots were quantified. Significantly different protein spots were identified by two mass spectrometry principles, nano-LC-ESI-MS/MS and by nano-LC-ESI(CID/ETD)-MS/MS. Signaling, chaperone and metabolic enzyme proteins were linked to memory enhancement.