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Cobalt-Catalyzed Enantioselective Intramolecular Hydroacylation of Ketones and Olefins
journal contribution
posted on 2014-12-03, 00:00 authored by Junfeng Yang, Naohiko YoshikaiCobalt–chiral
diphoshine catalytic systems promote intramolecular
hydroacylation reactions of 2-acylbenzaldehydes and 2-alkenylbenzaldehydes
to afford phthalide and indanone derivatives, respectively, in moderate
to good yields with high enantioselectivities. The ketone hydroacylation
did not exhibit a significant H/D kinetic isotope effect (KIE) with
respect to the aldehyde C–H bond, indicating that C–H
activation would not be involved in the rate-limiting step.