posted on 2022-03-17, 20:04authored byWenxin Lu, Yongmei Zhao, Fanke Meng
Catalytic sequential hydrosilylation
of 1,3-enynes and 1,4-enynes
promoted by cobalt complexes derived from bisphosphines are presented.
Site- and stereoselective Si–H addition of primary silanes
to 1,3-enynes followed by sequential intramolecular diastereo- and
enantioselective Si–H addition afforded enantioenriched cyclic
alkenylsilanes with simultaneous construction of a carbon-stereogenic
center and a silicon-stereogenic center. Reactions of 1,4-enynes proceeded
through sequential isomerization of the alkene moiety followed by
site- and stereoselective hydrosilylation. A wide range of alkenylsilanes
were afforded in high efficiency and selectivity. Functionalization
of the enantioenriched silanes containing a stereogenic center at
silicon delivered a variety of chiral building blocks that are otherwise
difficult to access.