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Cobalt-Catalyzed Selective Functionalization of Aniline Derivatives with Hexafluoroisopropanol

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journal contribution
posted on 20.12.2018, 18:32 by He Zhao, Shuo Zhao, Xiu Li, Yinyue Deng, Huanfeng Jiang, Min Zhang
A cobalt-catalyzed site-selective functionalization of aniline derivatives with hexafluoroisopropanol, which enables the synthesis of a wide array of fluoroalkylated anilines, a class of highly valuable building blocks for further preparation of fluorinated functional products, is reported. The developed transformation proceeds with operational simplicity, use of earth-abundant metal catalyst, broad substrate scope, good functional group tolerance, and mild reaction conditions.