ol8b02892_si_001.pdf (11.4 MB)
Cobalt-Catalyzed α‑Methoxymethylation and Aminomethylation of Ketones with Methanol as a C1 Source
journal contribution
posted on 2018-10-15, 18:51 authored by Jingya Yang, Shuwen Chen, Hongyan Zhou, Chengqi Wu, Ben Ma, Jianliang XiaoUsing methanol as
a sustainable C1 source, cobalt-catalyzed α-methoxymethylation
and α-aminomethylation of ketones have been developed. With
cheap CoCl2·6H2O as catalyst and TBHP as
oxidant, the methoxymethylated products were obtained within a short
reaction time in up to 91% yield. Based on the observed reversibility
of methoxy adduct to enone, the α-aminomethylation of ketones
was then achieved by a one-pot methylenation/aza-Michael addition
sequence. In addition, an easy way to convert α-methoxymethyl
ketones to α-aminomethyl ketones has been discovered.