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Cobalt-Catalyzed Ligand-Controlled Regioselective Hydroboration/Cyclization of 1,6-Enynes

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journal contribution
posted on 01.12.2016, 00:00 by Tuo Xi, Zhan Lu
A ligand-controlled cobalt-catalyzed regioselective hydroboration/cyclization of 1,6-enynes with HBPin was developed by switching the size of the coordinated side arm to afford alkenylboronates and alkylboronates, respectively. Gram-scale reactions could be easily conducted, which is beneficial for further derivatizations. A primary mechanism was proposed on the basis of substrate-controlled experiments and deuterium experiments.