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Cobalt-Catalyzed Hypervalent Iodine(III) Promoted Cascade Annulation Reaction of Anilines with Formamides for 2‑Aminobenzoxazoles Synthesis

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journal contribution
posted on 2023-05-17, 14:44 authored by Lipeng Long, Xin Li, Yu Wang, Xing Su, Liang Qiao, Wenjun Luo, Zhengwang Chen
Herein, we disclose a practical and simple procedure to synthesize 2-aminobenzoxaoles. Simple anilines and formamides were used as substrates. The C–H bond ortho to the amino group in the anilines was directly functionalized under cobalt-catalyzed conditions with high levels of functional group tolerance. Hypervalent iodine(III) was both an oxidant and a Lewis acid for this reaction. The mechanism study showed that this transformation may involve a radical process.

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