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Cobalt-Catalyzed Heck-Type Reaction of Alkyl Halides with Styrenes

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journal contribution
posted on 15.05.2002, 00:00 by Yousuke Ikeda, Tomoaki Nakamura, Hideki Yorimitsu, Koichiro Oshima
A cobalt complex, CoCl2[1,6-bis(diphenylphosphino)hexane], catalyzes an alkylation reaction of styrenes in the presence of Me3SiCH2MgCl in ether to yield β-alkylstyrenes. A variety of alkyl halides including alkyl chlorides can be employed as an alkyl source. A radical mechanism is strongly suggested for this alkylation reaction.

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