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Cobalt-Catalyzed C(sp2)–H Allylation of Biphenyl Amines with Unbiased Terminal Olefins

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journal contribution
posted on 23.11.2020, 18:33 by Alessio Baccalini, Stefania Vergura, Pravas Dolui, Siddhartha Maiti, Subhabrata Dutta, Soham Maity, Farheen Fatima Khan, Goutam Kumar Lahiri, Giuseppe Zanoni, Debabrata Maiti
Unactivated olefins usually react poorly in conventional alkenylation reactions. Their introduction via C–H activation is limited to aromatic acids. Herein, we disclose a C–H functionalization protocol of aromatic amines with unactivated olefins, which shows exclusive allylic selectivity for the distal ring of the biphenyl system by exploiting a readily available cobalt­(II) catalyst. The allylation proceeds smoothly involving a broad set of unbiased olefins and biaryls, giving access to the functionalization of the biphenyl scaffold.