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Cobalt-Catalyzed α‑Arylation of Substituted α‑Halogeno β‑Lactams

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journal contribution
posted on 07.08.2019, 19:15 by Vanessa Koch, Mélanie M. Lorion, Etienne Barde, Stefan Bräse, Janine Cossy
The treatment of 3-bromo β-lactams by an aryl Grignard, in the presence of CoCl2 (2 mol %) and TMEDA (2 mol %) in THF, produces 3-aryl β-lactams in good yields and excellent diastereoselectivity.