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Co2(CO)8 as a Solid CO (g) Source for the Amino Carbonylation of (Hetero)aryl Halides with Highly Deactivated (Hetero)arylamines

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journal contribution
posted on 07.04.2021, 18:10 by Srinivas Cheruku, Ayyiliath M Sajith, Yatheesh Narayana, Poornima Shetty, Sandhya C Nagarakere, Kunigal S Sagar, Kumara N Manikyanally, Kanchugarkoppal Subbegowda Rangappa, Kempegowda Mantelingu
Carbonylation of (hetero)­aryl iodides/bromides with highly deactivated 2-aminopyridines using Pd–Co­(CO)4 bimetallic catalysis is accomplished. The use of Co2(CO)8 as a solid CO­(g) source enhanced reaction rates observed when compared to CO­(g), and excellent yields highlight the versatility of the developed protocol. A wide range of electronically and sterically demanding heterocyclic amines and (hetero)­aryl iodides/bromides employed for this study resulted in excellent yields of amino carbonylated products. The developed methodology was further extended to synthesize Trypanosome brucie and luciferase inhibitors.

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