Co2(CO)8 as a Solid CO (g) Source for the Amino Carbonylation of (Hetero)aryl Halides with Highly Deactivated (Hetero)arylamines
journal contributionposted on 07.04.2021, 18:10 by Srinivas Cheruku, Ayyiliath M Sajith, Yatheesh Narayana, Poornima Shetty, Sandhya C Nagarakere, Kunigal S Sagar, Kumara N Manikyanally, Kanchugarkoppal Subbegowda Rangappa, Kempegowda Mantelingu
Carbonylation of (hetero)aryl iodides/bromides with highly deactivated 2-aminopyridines using Pd–Co(CO)4 bimetallic catalysis is accomplished. The use of Co2(CO)8 as a solid CO(g) source enhanced reaction rates observed when compared to CO(g), and excellent yields highlight the versatility of the developed protocol. A wide range of electronically and sterically demanding heterocyclic amines and (hetero)aryl iodides/bromides employed for this study resulted in excellent yields of amino carbonylated products. The developed methodology was further extended to synthesize Trypanosome brucie and luciferase inhibitors.