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Co-Catalyzed Direct Regio- and Enantioselective Intermolecular γ‑Amination of N‑Acylpyrazoles

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journal contribution
posted on 22.12.2020, 22:14 by Xin Fu, Yu Hao, He-Yuan Bai, Abing Duan, Shu-Yu Zhang
A cobalt-catalyzed regio- and enantioselective γ-amination of β,γ-unsaturated N-acylpyrazoles that delivers the corresponding γ-amination products in good regio- and enantioselectivity has been established. Moreover, the nitrogen-containing compounds could be easily synthesized. DFT calculations have been provided to explain regio- and enantioselectivity for this γ-amination. The chiral γ-amination products were readily converted into the chiral γ-amino acid derivatives.