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Download fileClickable Multifunctional Large-Pore Mesoporous Silica Nanoparticles as Nanocarriers
journal contribution
posted on 2018-01-11, 00:00 authored by Hsin-Yi Chiu, Dorothée Gößl, Lisa Haddick, Hanna Engelke, Thomas BeinLarge-pore
mesoporous silica nanoparticles (LP-MSNs) with defined
particle size (<200 nm) are promising carrier systems for the cellular
delivery of macromolecules. Ideal nanocarriers should be adaptable
in their surface properties to optimize host–guest interactions;
thus, surface functionalization of the nanovehicles is highly desirable.
In this study, we synthesized various monofunctional LP-MSNs by incorporating
different organic groups into the silica framework via a co-condensation
approach. Further, we applied a delayed co-condensation strategy to
create spatially segregated core–shell bifunctional LP-MSNs.
Diverse particle morphologies were obtained by adding different organosilanes
to the silica precursor solution. The effect of organosilanes in the
co-condensation process on particle size and pore structure formation
is also discussed. Surface functional groups were then used for binding
stimuli-responsive linkers. These were finally exploited for copper-free
click chemistry for cargo conjugation to create a delivery system
with controlled cargo release. Model cargo release experiments in
buffer using these new multifunctional LP-MSNs demonstrate their ability
in controlled cargo uptake and release and their potential for biomolecule
delivery.
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Keywords
multifunctional LP-MSNsDiverse particle morphologiescargo releasepore structure formationModel cargo release experimentsbinding stimuli-responsive linkersorganosilanebiomolecule deliverycarrier systemsmonofunctional LP-MSNsdelivery systemsurface propertiesco-condensation strategycargo conjugationcargo uptakeparticle sizeco-condensation processsilica precursor solutionco-condensation approachsurface functionalizationIdeal nanocarriersClickable Multifunctional Large-Pore Mesoporous Silica Nanoparticlescopper-free click chemistryNanocarriers Large-pore mesoporous silica nanoparticlessilica framework