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Clerodane Diterpenoids from Croton crassifolius

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journal contribution
posted on 28.12.2012, 00:00 by Guo-Cai Wang, Jia-Gui Li, Guo-Qiang Li, Jiao-Jiao Xu, Xia Wu, Wen-Cai Ye, Yao-Lan Li
Seven new clerodane diterpenoids (17) were isolated from roots of Croton crassifolius, along with six known compounds. The structures were elucidated by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D NMR), and the structures of 1, 3, 4, and 7 were confirmed by single-crystal X-ray diffraction analyses. Compounds 113 were evaluated for in vitro antiviral activity against herpes simplex virus type 1 using the cytopathic effect reduction assay.