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Cinnamtannin D‑1 Protects Pancreatic β‑Cells from Palmitic Acid-Induced Apoptosis by Attenuating Oxidative Stress
journal contribution
posted on 2014-06-04, 00:00 authored by Ting Wang, Peng Sun, Liang Chen, Qi Huang, Kaixian Chen, Qi Jia, Yiming Li, Heyao WangIn previous studies, A-type procyanidin oligomers isolated from Cinnamomum tamala were proved to possess antidiabetic
effect and protect pancreatic β-cells in vivo. The aim of this
study was to unveil the mechanisms of protecting pancreatic β-cells
from palmitic acid-induced apoptosis by cinnamtannin D-1 (CD1), one
of the main A-type procyanidin oligomers in C. tamala. CD1 was discovered to dose-dependently reduce palmitic acid- or
H2O2-induced apoptosis and oxidative stress
in INS-1 cells, MIN6 cells, and primary cultured murine islets. Moreover,
CD1 could reverse palmitic acid-induced dysfunction of glucose-stimulated
insulin secretion in primary cultured islets. These results indicate
that reduction of apoptosis and oxidative stress might account for
the protection effect of CD1, which provided a better understanding
of the mechanisms of the antidiabetic effects of procyanidin oligomers.