American Chemical Society
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Chromium-Catalyzed Activation of Acyl C–O Bonds with Magnesium for Amidation of Esters with Nitroarenes

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journal contribution
posted on 2019-03-05, 17:36 authored by Liang Ling, Changpeng Chen, Meiming Luo, Xiaoming Zeng
Here, we report a chromium-catalyzed activation of acyl C–O bonds with magnesium for amidation of esters with nitroarenes. Low-cost chromium­(III) chloride shows high reactivity in promoting amidation by using magnesium as reductant and chlorotrimethylsilane as additive. It provides a step-economic strategy to the synthesis of centrally important amide motifs using inexpensive and air-stable nitroarenes as amino sources.