ol500954j_si_001.pdf (4.35 MB)
Chiral Phosphoric Acid-Catalyzed Asymmetric Transfer Hydrogenation of Quinolin-3-amines
journal contribution
posted on 2014-05-16, 00:00 authored by Xian-Feng Cai, Ran-Ning Guo, Guang-Shou Feng, Bo Wu, Yong-Gui ZhouA chiral
phosphoric acid catalyzed asymmetric transfer hydrogenation
of aromatic amines, quinolin-3-amines, was successfully developed
with up to 99% ee. To supplement our previous work on the Ir-catalyzed
asymmetric hydrogenation of 2-alkyl substituted quinolin-3-amines,
a number of 2-aryl substituted substrates were reduced to provide
a series of valuable chiral exocyclic amines with high diastereo-
and enantioselectivities.