ol9b01637_si_001.pdf (13.36 MB)
Chiral Hydroxytetraphenylene-Catalyzed Asymmetric Conjugate Addition of Boronic Acids to Enones
journal contributionposted on 2019-06-19, 17:08 authored by Guo-Li Chai, A-Qiang Sun, Dong Zhai, Juan Wang, Wei-Qiao Deng, Henry N. C. Wong, Junbiao Chang
(S)-2,15-Br2-DHTP-catalyzed asymmetric conjugate addition of boronic acids to β-trifluoromethyl α,β-unsaturated ketones and enones was studied. The reaction afforded the corresponding Michael addition products in moderate to high yields with excellent enantioselectivities (up to 99:1 er). This catalytic system features mild reaction conditions, high efficiency, and tolerance to heteroarylboronic acids.