Chiral Discrimination by a Binuclear Pd Complex Sensor Using ³¹P{¹H} NMR

An axially chiral binuclear μ-hydroxo Pd complex (BPHP) first served as an excellent chiral sensor for discriminating a variety of analytes including amino alcohol, amino amide, amino acid, mandelic acid, diol, diamine, and monoamine by ³¹P­{¹H} NMR. A detailed recognition mechanism was proposed based on the single crystal and mass spectrum of Pd-complexes. In general, BPHP sensor, through extracting the acidic hydrogen of an analyte by its Pd–OH group, forms stable diastereomeric complexes with two enantiomers of the analyte giving well distinguishable split ³¹P­{¹H} NMR signals for chiral discrimination.