American Chemical Society
ja207748r_si_001.pdf (13.41 MB)

Chiral Allene-Containing Phosphines in Asymmetric Catalysis

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journal contribution
posted on 2016-02-22, 15:13 authored by Feng Cai, Xiaotao Pu, Xiangbing Qi, Vincent Lynch, Akella Radha, Joseph M. Ready
We demonstrate that allenes, chiral 1,2-dienes, appended with basic functionality can serve as ligands for transition metals. We describe an allene-containing bisphosphine that, when coordinated to Rh(I), promotes the asymmetric addition of arylboronic acids to α-keto esters with high enantioselectivity. Solution and solid-state structural analysis reveals that one olefin of the allene can coordinate to transition metals, generating bi- and tridentate ligands.