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Chiral-at-Metal Rh(III) Complex Catalyzed Asymmetric Conjugate Addition of Unactivated Alkenes with α,β-Unsaturated 2‑Acyl Imidazoles

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journal contribution
posted on 08.06.2017, 11:55 by Kuan Li, Qian Wan, Qiang Kang
A newly prepared chiral-at-metal Rh­(III) complex catalyzed highly efficient asymmetric conjugate addition of para-vinylanilines with α,β-unsaturated 2-acyl imidazoles is developed, affording the corresponding adducts in 67–95% yields with 86–95% ee. Remarkably, employing as low as 0.05 mol % of Rh­(III) complex as catalyst, a gram-scale reaction still affords the desired product in 81% yield with 92% ee.

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