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Chemoselective Synthesis of α‑Amino-α-cyanophosphonates by Reductive Gem-Cyanation–Phosphonylation of Secondary Amides

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journal contribution
posted on 06.05.2019, 19:14 by Ting-Ting Chen, Ai-E Wang, Pei-Qiang Huang
A novel approach to α-amino-α-cyanophosphonates has been developed. The method features a Tf2O-mediated reductive geminal cyanation/phosphonylation of secondary amides. Mild reaction conditions, high bond-forming efficiency, inexpensive readily available starting materials, and good to excellent yields with wide functional group compatibility constitute the main advantages of this method. The protocol can be run on a gram scale.