American Chemical Society
ja512389y_si_001.pdf (1.86 MB)

Chemoselective Hydrogenation of Carbonyl Compounds and Acceptorless Dehydrogenative Coupling of Alcohols

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journal contribution
posted on 2015-03-25, 00:00 authored by Denis Spasyuk, Cristian Vicent, Dmitry G. Gusev
OsHCl­(CO)­[κ3-PyCH2NHC2H4NHPtBu2] is the first efficient catalyst for chemoselective reduction of challenging unsaturated esters to enols and for acceptorless coupling of amines with MeOH and EtOH affording formamides and acetamides. The NMR, ESI-MS, and DFT data indicate a mechanism proceeding in the metal coordination sphere and producing no free organic intermediates.