ol9b02989_si_001.pdf (12.12 MB)
Download fileChemodivergent and Stereoselective Construction of gem-Difluoroallylic Amines from Masked Difluorodiazo Reagents
journal contribution
posted on 12.09.2019, 17:36 authored by Jun-Liang Zeng, Yue Zhang, Meng-Meng Zheng, Zhi-Qi Zhang, Xiao-Song Xue, Fa-Guang Zhang, Jun-An MaWe report a general
and efficient approach to construct achiral
and chiral gem-difluoroallylic amines from a masked
difluorodiazo reagent (PhSO2CF2CHN2) and readily available imines. This facile protocol takes advantage
of the phenylsulfonyl and diazo moieties as efficient activating and
directing groups to assist difluoroalkyl incorporation and facilitate
the chemodivergent and stereoselective formation of gem-difluoroallylic amines.