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Chemo- and Regioselective Functionalization of Polyols through Catalytic C(sp3)–C(sp3) Kumada-Type Coupling of Cyclic Sulfate Esters

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journal contribution
posted on 21.07.2016, 14:37 by Rodrigo Ramírez-Contreras, Bill Morandi
This contribution describes a copper-catalyzed, C­(sp3)–C­(sp3) cross-coupling reaction of cyclic sulfate esters, a distinct class of electrophilic derivatives of polyols, with alkyl Grignard reagents to afford functionalized alcohol products in good yields. The method is operationally simple and highlights the potential of cyclic sulfate esters as highly reactive substrates in catalytic, chemoselective polyol transformations.

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