np8b00778_si_001.pdf (1.86 MB)

Chemical Synthesis Study Establishes the Correct Structure of the Potent Anti-Inflammatory Agent Myrsinoic Acid F

Download (1.86 MB)
journal contribution
posted on 27.12.2018, 15:03 by Jiri Mikusek, Jeremy Nugent, Ping Lan, Martin G. Banwell
A total synthesis of compound 3 from p-bromophenol is reported and thereby establishing that this, rather than its cyclodehydrated counterpart 1 (as postulated originally), is the correct structure of the natural product myrsinoic acid F. The biological evaluation of compound 3 in a mouse-ear edema assay established that it is a significantly more potent anti-inflammatory agent than the NSAID indometacin.

History

Exports