posted on 2021-02-16, 15:35authored byMunhyung Bae, Emily Mevers, Gleb Pishchany, Sarah G. Whaley, Charles O. Rock, David R. Andes, Cameron R. Currie, Monica T. Pupo, Jon Clardy
Herein is a report
on the molecular exchange occurring between
multilateral symbiosis partnersa tit-for-tat exchange that
led to the characterization of two new metabolites, conocandin B (fungal-derived)
and dentigerumycin F (bacterial-derived). The structures were determined
by NMR, mass spectrometry, genomic analysis, and chemical derivatizations.
Conocandin B exhibits antimicrobial activity against both the bacterial
symbionts of fungus-growing ant and human pathogenic strains by selectively
inhibiting FabH, thus disrupting fatty acid biosynthesis.