Chelation-Assisted Palladium-Catalyzed Cascade Bromination/Cyanation Reaction of 2-Arylpyridine and 1-Arylpyrazole C−H Bonds

A chelation-assisted palladium-catalyzed cascade bromination/cyanation reaction of 2-arylpyridine and 1-arylpyrazole C−H bonds has been developed. Notably, the reaction employs K₃[Fe(CN)₆] as a safe and nontoxic cyanide source, providing aromatic nitriles in moderate to good yields in one-pot. The procedure tolerates methoxy, chloro, fluoro, cyano, trifluoromethyl, and carbomethoxy groups.